If not recognised, however, in time it may develop into the most severe manifestation of hypothyroidism known as myxedema coma. Identification requires analysis of thyroid hormones circulating in the bloodstream, and treatment is simply replacement with exogenous hormone, usually levothyroxine synthroid. Coma mixedematoso urgencias y otras situaciones especiales. Hypothyroidism is a frequently diagnosed and simply treated disease. The typical progression is lethargy evolving into stupor and, eventually. It is a medical emergency with a high mortality rate. Articulo especial coma mixedematoso resena historica. Abstract myxedema coma is the most severe and deepest form of hypothyroidism. The deadly manifestation of hypothyroidism is myxedema. An atypical case of myxedema coma with concomitant nonconvulsive seizure pratikpatel, 1 mikhaelbekkerman, 1,2 cristinavarallorodriguez, 1 andrajendrarampersaud 3 department of medicine, st. Pdf free download flatform start research documents.
Bradicardia hipoventilacin hipotermia y, ocasionalmente convulsiones. Myxedema coma is defined as severe hypothyroidism leading to decreased mental status, hypothermia, and other symptoms related to slowing of function in multiple organs. Some symptoms of myxedema coma include fatigue, lethargy, depression, dry skin, and weight gain. Coma mixedematoso national college enfermeria nurs3040 winter 2017 coma mixedematoso. Untreated or unrecognized hypothyroidism may progress to severe decompensated hypothyroidism or myxedema coma.
Among the unleashing factors found are sepsis, exposure to cold, acute. Hypothyroidism is a very common, yet often overlooked disease. Clinical data for our 5 patients and 82 cases from the medline search were pooled and factors associated with mortality were sought among age, gender, presence of cardiac or pulmonary complications, and doses of thyroid hormone by multiple. Factors associated with mortality of myxedema coma. Broadway, yonkers, ny, usa lake erie college of osteopathic medicine, w grandview blvd, erie, pa, usa. Case report an atypical case of myxedema coma with. Memorias simposio actualizacion endocrinologia medicas uis 2015. The typical characteristics of myxedema coma, including bradycardia, hypotension, and hypothermia, were absent in this case. Myxedema coma or myxedema crisis is a lifethreatening complication of hypothyroidism. The diagnosis of myxedema coma was made based on the patients clinical presentation and a score of 65 on the diagnostic scoring system published in 2014 by popoveniuc et al.
The term myxedema coma is generally seen as misleading since most patients do not initially present in a coma. Most patients, however, are not comatose, and the entity rather represents a form of very severe, decompensated hypothyroidism. Mild myxedema coma usually is treated by a general practitioner or internist while moderate to severe myxedema coma is treated and managed by an endocrinologist. It can have a myriad of signs and symptoms, and is often nonspecific. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, bradycardia, and altered mental status in the setting of severe hypothyroidism. An atypical case of myxedema coma with concomitant. Pdf hypothyroidism is a frequently diagnosed and simply treated disease. Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Relatively few cases are reported in the literature since the first case was apparently reported from the st.
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